Antibody humanization is used to reduce the immunogenicity of animal monoclonal antibodies and enhance their activity within the human immune system. Healsun Biopharm can design appropriate humanized sequences based on the mouse-derived antibody sequences and attempt to remove PTM sites during the humanization design process to address drug-related risks at an early stage.
The client's sequence will be optimized using a screening library approach to address concerns, construct improved vectors, and confirm retained activity.